study subjects have shown that there is a weakness for chocolate in individuals who are under emotional stress, bored, upset, or feeling down. Eur J Clin Nutr. Exp Biol Med (Maywood). 36 In another study, a half-maximal, flow-mediated dilation 2 hours after consumption was achieved with 616 mg total flavanols. A similar result also has been shown with cocaine craving. An in vitro study showed that breast cancer cells are selectively susceptible to the cytotoxic effects of cocoa -derived pentameric procyanidin and suggest that inhibition of cellular proliferation by this compound is associated with the sire-specific dephosphorylation or down-regulation of several cell cycle regulatory proteins. Mester R, Toren P, Mizrachi I, Wolmer L, Karni N, Weizman. The fruits are borne on the trunk and branches, with the seeds imbedded in a sticky pulp. Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week.
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15 The pharmacologically active ingredients of cocoa seeds include amines, alkaloids, fatty acids, polyphenols (including flavonoids tyramine, magnesium, phenylethylamine, and N-acylethanolamines. In another study, 4 34,489 cardiovascular disease-free postmenopausal women were followed for 16 years. 41 Results of another study demonstrated that daily consumption of a high-flavanol cocoa drink led to a sustained reversal of endothelial dysfunction, reaching a plateau level of improved flow-mediated dilation after 5 days. Vlachopoulos C, Aznaouridis K, Alexopoulos N, Economou E, Andreadou I, Stefanadis. Handbook of Medicinal Herbs. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging. A cultural history of the medicinal and ritual use for chocolate.